Lean Mass Hyper-responder Measurement Study

We are seeking to help provide wide spectrum blood panels and cardiovascular testing for “Lean Mass Hyper-responders” – typically those on a low carb diet with very high cholesterol, yet very low triglycerides.

85.51% Raised
$279,627.00 donated of $327,000.00 goal
629 Donors

[UPDATE: Study is now underway for both LMHRs and borderline LMHRs — please visit https://citizensciencefoundation.org/study/ for more information]

[UPDATE: We’ve now changed the campaign to a $100,000 goal —once reached, we’ll be matched by an anonymous donor to bring us to $200,000 total!]

The Lean Mass Hyper-responder (LMHR) phenotype is characterized by very high LDL cholesterol of 200 mg/dL or higher, HDL-C of 80 mg/dL or higher, and Triglycerides of 70 mg/dL or lower . We are likewise interested in “borderline” LMHRs that are near these same cut points.

We are seeking to help provide wide spectrum blood panels and cardiovascular testing such as CT Angiogram, Carotid Intima Media Thickness (CIMT), and Coronary Artery Calcium (CAC) score to this phenotype of interest where we likewise confirm no genetic Familial Hypercholesterolemia.

We further wish to encourage ongoing communication and follow up with participants, including a further set of measurements in five years.

121 Replies to “Lean Mass Hyper-responder Measurement Study”

  1. Hi Dave,

    I’m registering interest as a LMHR (TC394, HDL100, T72)abroad – I’m in the UK.

    I’ve provided my lipid details at cholesterolcode previously and follow your work with great interest. I’m cambridge_pt on twitter.

    Good luck with the project – so looking forward to the further understanding!

    All the best,

  2. Hi Dave ,
    I’ve been following your craziness for a while. Bravo !
    I told my PMD ( lipid specialist ) that I was a hyper-responder and he said “ what ?? “. .
    I started out Total Chol 410 / LDL 280/ HDL/110, and Try 45. I have since been dx with Familial Hypercholesteremia .
    My history is Weston A Price. While foods diet for 15 yrs , watching my cholesterols rise , but not worried till over 400. Chris Masterjohn told me I aight to think about FH. So I call Dr Dayspring and was refreshing to John West a lipid specialist in Atlanta , GA where I live.
    First , on my own I cut my massive intake of meat and coconut oil down very low. The numbers were cut down 30%. But my Calcium score put me in the 98% for my age ( 65). So I agreed after much consternation , to take Crestor 5 mg /day. Interestingly , I took Zetia also and my number drastically reduced. I wanted to take Zetia only , but with the documented CAD on calcium scan , I was advised low dose Crestor was warranted.
    I’m thinking I’m a possible candidate for your study
    Your thoughts
    [Contact info redacted]
    Would love to hear from you !

  3. Hi Dave,

    I live in Portugal and I think I’m a LMHR, or at least close to it, becouse I did the feldman protocol last week and the result were:

    22-10-2019 25-10-2019
    TC – 367 291
    HDL – 83 109
    LDL(calc) – 263 169
    TG – 104 64

    I’m interested in being part of this project, what can I do?

    Please continue what you’re doing, You’re changing the world for the best!

  4. Hi Dave,

    I live in Portugal and I might be a LMHR since I did the feldman Protocol last week and the results were:

    TC – 367
    HDL – 83
    LDL – 263
    TG – 104

    TC – 291
    HDL – 109
    LDL – 169
    TG – 64

    I’m interested in being part of this project. What can I do?

    Please continue what you’re doing, you’re great and you are changing the world for the best

  5. I’m UK based, 58 on keto (below 20g carbs) since June. Dr trying to push me to take statin, BP is 110/70, BMI 22, 130lbs. Below – mg/dL is my conversion from mmol/L).
    TC – 219.6 mg/dL (12.2 mmol/L)
    Trig – 15.2 mg/dL (0.84 mmol/L)
    HDL – 25.38 mg/dL (1.41 mmol/L)
    LDL – 187.20 mg/dL (10.4 mmol/L)
    Plasma fasting glucose – 88.2 mg/dL (4.9 mmol/L)

    1. Sharon:

      All your lipid conversions from mmol/L to mg/dL are wrong.

      I have corrected them:

      TC = 12.2 mmol/L x 38.6 = 470.9 mg/dL
      Trig = .84 mmol/L x 88.5 = 74.3 mg/dL
      HDL = 1.41 mmol/L x 38.6 = 54.4 mg/dL
      LDL = 10.4 mmol/L x 38.6 = 401.4 mg/dL

      Your Plasma fasting glucose conversion is correct.

  6. I am willing to participate as well. These values were after 2 months on keto and are a year ago (11/18).

    TC 302
    Triglycerides 30
    HDL 110
    Non-HDL 192
    LDL 186

  7. Hi Dave,
    US citizen living in EU.
    June 2017 started Primal BluePrint Diet due to TIA.
    No statins or any meds.
    HDL @ 1.4 / 54.1
    LDL @ 3.5 (135.3)
    TRIG – 2.4 (212.6)
    Ratio – 4.3

    Started Keto LCHF around mid 2018
    HDL @ 2.18 (84.3)
    LDL @ 4.38 (166.3)
    TRIG – 0.66 (58.5)
    Ratio – 3.4

    Started Carnivore Flexible around May 2019
    HDL @ 2.38 (92.0)
    LDL @ 7.88 (304.7)
    TRIG – 0.87 (77.1))
    Ratio – 4.6

    Still not taking Statins & any meds. Let’s hope this is the right way… 🙂

  8. Hi Dave,
    I am big fan of your work and I will be happy if I can help this cause. I live in Bulgaria and I hope this is not going to be a problem.
    I started LCHF with pure curiosity as I never had problems with my weight.
    I have made some tests 3 months ago( after 4 months on KETO) and my numbers are as follows:
    Cholesterol total 7,63 mmol/l
    Triglycerides 0.61 mmol/l
    HDL- cholesterol 2,12 mmol/l
    LDL- cholesterol 4,70 mmol/l
    VLDL – cholesterol 0.28 mmol/l

    Next week I am going to make new tests and I will include APO -A and APO-B.

    Best regards

    1. Hi Petko,

      Your numbers surprising mirror mine. Here are mine.

      Cholesterol total 7,4 mmol/l
      Triglycerides 0.51 mmol/l
      HDL- cholesterol 2,10 mmol/l
      LDL- cholesterol 4,50 mmol/l

      With these numbers I am avoiding my GP who is doing his best to get hold of me.

      I am naturally lean and do not exercise other than walking and doing everyday chores. I would therefore ask Dave if his definition for LMHR must included only those who are athletic?

      I cut out the carbs 10 months ago.

      Anything I can do to help with this project?

  9. I’d also love to participate in this project. LMHR here
    LDL 200
    HDL 90
    TRI 48
    NON HDL 200

    Been eating mostly low carb/keto for 8+ years

  10. I was at the Low Carb Houston Conference and I’m interested in being a subject for the project. My last LDL was measured as 504. My HDL was 81. However , my Triglycerides were 128.

  11. I’m in Canada and would love to help be a test.
    Total 10.15 mmol
    HDL 2.32 mmol
    LDL 7.48
    Tri .77

  12. I am interested in this project, as I’ve always had a total cholesterol around 200, but after eating low carb, and keto, my numbers Dec 2018 were as follows:

    Total cholesterol: 288
    HDL: 78
    LDL: 197
    TG: 67

    I’m interested in the relationship between eating low carb/high fat and CV risk factors, rather than just using cholesterol numbers to decide if one needs to take medication. I work as a nurse practitioner in inpatient cardiothoracic surgery, so I see plenty of patients that could benefit from diet changes that could help them avoid a repeat trip.

    Thank you for starting this project.
    Jen Fox,

  13. Also interested in participating. I have been strict carnivore for 2 years. Recently had bloods done:
    16 hrs water fasted
    Total cholesterol: 478mg/dL / 12.36mmol/L
    LDL: 377md/dL / 9.76mmol/L
    HDL: 84mg/dL / 2.17mmol/L
    TG: 84mg/dL / 0.95mmol/L

    I am 51kg, lean & very active – strength training 5-6 times per week, some cardio, HIIT and walk every day.

    1. I am like you with the numbers ( almost), also lean-ish and do resistance weight training. Did you get into the study? The posts seems to be all 2019

      1. The Lean Mass Hyper-responder study had some delays due to COVID what with travel restrictions, social distancing, and other potential impacts, but we’ve still been working on putting it together and hope to have an update we can share on the status of the IRB approval, etc, soon.

  14. Hi Dave. Just donated. If you are looking for LMHR volunteers I’m happy to be considered. What is the process to get involved in the project? My numbers put me well into the LMHR camp and my CAC score is Zero.

  15. Hi Dave.
    I too have been following your work and would like to be considered for the trial.
    I live in the UK and aged 56
    My numbers are:
    Total Col : 332 (8.6)
    LDL : 212 (5.5)
    HDL: 108 (2.8)
    Tri: 53 (0.6)
    Keep up the good work.

  16. Hi Dave. I’d be a volunteer if needed : age 61, keto for 2 yrs.
    LDL- 181
    HDL- 99
    TRIG- 53

  17. Hi Dave and Siobhan,
    I am supporting your efforts. Retired and meet the criteria but am not lean.
    Healthy, no drink or smoke, no stress
    CAC 0
    Both carotid arteries clear
    No meds
    Cooperative MD
    Strict carnivore for last 3 weeks
    KETO last 12 months
    Lost 30 pounds 10 more to go
    Work out
    Let me know how I can help.

  18. Hi I definitely fit the criteria of a lean mass hyper responder and would love to take part in your study! Keto for 2 1/2 years now. 44 yo female. Height 5’4” 140lbs. Approx 20% bf. Last lipid panel 10-7-19.
    LDL 180
    HDL 110
    VLDL 9
    Trig. 46
    Total Cholesterol 299
    And had a CAC scan with a score of zero

  19. Hi, I’m Simon from Prevost, Quebec, Canada.
    I pretty sure i’m a lmhr.
    I’m 55 years old ,1.80 m./ 72 kg. athetic shape, very lean and muscular.
    Lot’s of training ( hiit , resistance, running, walking etc.
    Keto for 3 years and borderline carnivore for 4 months.
    Total cholest. 9.92 mmol/l
    Total ldl cholest. 7.26 mmol/l
    Hdl cholest. 2.25 mmol/l
    Triglyc. 0.89 mmol/l
    Protein C reactive: 0.3 mg/l
    Sorry for my english but i am french.
    Thankyou very much for your researchs.

  20. Hey Dave,

    I’d like to volunteer for your project if I can be of help. I’ve been keto/carnivore for about 1.5 yrs. I admit I have trouble staying completely constant but I strive for it (carbs <=20) 🙂 Here are my lab numbers:

    TOTAL 349
    TRI 66
    HDL 111
    LDL 238
    VLDL not measured

    TOTAL 402
    TRI 77
    HDL 99
    LDL 288
    VLDL 15

    I am located in Maryland. I am 65 yrs old, 5'1'' and weigh about 110 lbs. Although I am on the smaller side, I do not work out and I am not muscular like those in the pictures you display. I am very interested in your project and thankful for how this WOE has improved my health. I am grateful for all of the ways that your work and presence on the internet have helped me. I hope I can be of help to you in return, please let me know.

  21. Female. 46. Texas.
    Total 316
    LDL 190
    HDL 112 (triathlalon training 🙂
    TG 68

    Appreciate all you are doing.

  22. Hello Dave been on low carb diet for about two years and my numbers have only gotten better I would love to be used for your study

  23. Over 2 years on keto/ZC.
    2016 numbers
    Total 197
    LDL 122
    HDL 61
    Trigs 72
    2017 numbers
    Total 313
    LDL 230
    HDL 72
    Trigs 56

    44yrs old
    BF 10-15%
    Lift 4x a week

    Borderline LMHR and probably would have lower trigs but I love coffee lol.

  24. This paper should be of interest:

    Cureus. 2018 Apr; 10(4): e2452.
    Published online 2018 Apr 9.
    doi: 10.7759/cureus.2452
    PMCID: PMC5991918
    PMID: 29888156
    A 72-Year-Old Patient with Longstanding, Untreated Familial Hypercholesterolemia but no Coronary Artery Calcification: A Case Report
    Monitoring Editor: Alexander Muacevic and John R Adler
    Kipp W Johnson, Joel T Dudley, and Jason R Bobe

  25. Hi Dave, I would be interested in contributing any way I can. Recently Identified as a LMHR. Data below from 11.06.2019

    –===== CholesterolCode.com/Report v0.9.5.15 =====–
    • Male • 57 • Coffee: 3 cups/day •
    • 8 on months on Carnivore/Zero Carb/Meat Only •
    • 63h water fasted • Cholesterol Rx: none •

    Total Cholesterol: 314 mg/dL 8.12 mmol/L
    LDL Cholesterol: 213 mg/dL 5.51mmol/L
    HDL Cholesterol: 89 mg/dL 2.3mmol/L
    TG Cholesterol: 58 mg/dL 0.65mmol/L

  26. * Male 37, 1Y on carinivore diet
    * Endurance runner

    Cholesterol total: 10,10 mmol/L 390 mg/dL
    LDL: 6,89 mmol/L 266 mg/dL
    HDL 2,90 mmol/L 112 mg/dL
    Triglycerides: 0.66 mmol/L 58 mg/dL

  27. not sure posted, but I’d like to be considered in the project.
    59.5 years old 5ft 7 123 labs
    since starting lchf May 2017, my cholesterol just keeps going up and up (total and ldl)…I had increased my ‘fatty meat’, bacon, bacon grease, butter and eggs over period of time starting approx. late April early May 2019… and went ‘carnivorish’ for approx. 1 month prior to lab draw on 11/11/19. RESULTS: TOTAL C 411, LDL C 306, HDL 89 and Trig 56..SO< I decided to have 1st NMR test done.. I cut back on a little of the eggs, bacon, butter in the time frame.. and on 11/23/19 TOTAL C was 361, LDL C 243, HDL 109 and Trig 43. TOTAL LDL P particles 2342!..but, <90 Small LDL P, HDL-P 33 and LDL size 21.7….Now going to have Lp(a) drawn tomorrow….and probably CPR and Homocysteine soon?….thanks

  28. Male, 45yo on strict keto for 3 years, with <20g net carbs per diem

    Total cholesterol: 21.5 mmol/L
    HDL: 2.1 mmol/L
    LDL: 18.3 mmol/L
    Triglycerides: 2.5 mmol/L
    Fasting glucose: 5.2 mmol/L
    BP: 120/80
    CRP: Indistinguishable owing to low level
    CAC: 0
    Bodyweigh: 62kg
    Bodyfat: 11% via DEXA scan

    HIIT training: 4-6 times per week
    Resistance training: 2-3 times per week
    Racquetball 2 times per week

    Still awaiting LDL-C and LDL-P counts at present.

  29. Hi, I’m interested to participate in this project.
    I’m 43 year old male in New Zealand.
    I’ve been LCHF for 15 months, and greatly enjoy reading and watching the tremendous work you and the low carb movement (Ivor, Aseem, et al) continue to provide.
    You finally gave me the confidence to come off statins 6 months ago.
    Here is last weeks lipid panel;
    TC: 7.9
    TRIG: 0.7
    HDL: 2.01
    LDL: 5.6


  30. Hi. I’m also willing to be a part of the study. I live in WA state and am 59 yrs old. Have been low carb since March 2019 and freaked out my doctor with my last blood tests in September.
    Total Cholesterol 284
    HDL 83
    LDL 190
    Triglycerides 54
    CAC 0
    I’m due for new blood tests this month. LDL may be higher now because I’m working towards carnivore. Will be doing a lipid size/type breakdown with this round of blood work to make Dr happy. According to your calculator I fall into the LMHR category but I’m not super lean or athletic although I have lost fat and gained muscle with this diet. We do a body composition analysis along with bloodwork every 3 months. Last check BMI was 22.8 and BFM was 31.2.
    Thanks for doing this work! Donated today.

  31. I’m willing to participate and remove coffee if needed. 🙁

    Male, Age 56, Active, body fat ~10%, Keto/LCHF Since Aug 2018

    ———- 6/14/2019 ———-
    TC – 341
    HDL – 75
    LDL – 248
    VLDL – 18
    TG – 92
    CRP – .35

    Large VLDL-P – <0.8 (<=2.7 nmol/L)
    Small LDL-P – 216 (=4.8 umol/L)
    VLDL Size – No sufficient for VLDL size determination
    LDL Size – 22.3 (>=20.8 nm)
    HDL Size – 9.7 (>=9.2 nm)
    LP-IR Score – <25 (<=45 )

    ———- 10/26/2019 ———-
    TC – 350
    HDL – 85
    LDL – 247
    VLDL – 18
    TG – 90
    CRP – .46


  32. Hi Dave,
    How do we participate in this project? Both my mother and I are LMHRs. At 7 months on Keto:
    Tot: 497
    LDL: 383
    HDL: 99
    Trig: 59
    Previous to Keto, total was always at 200 or just above.

    Thanks for your work!

  33. Hey Dave, I might be on the border but I’d be interested in participating if you could use me. Currently living in Omaha, Nebraska. Doc was giving me a hard time about my LDL yesterday so I’d love to get him some good information.
    28 yr old Male. 5’6″, 151 lbs (13% BF). LCHF for about 8 months now. Results from 2 faster lipid panels are below. First number indicates Dec 2018 and the second is Dec 2019.
    TC- 236/268
    HDL- 69/69
    LDL- 149/188
    TG- 90/53

  34. Hi Dave, Here are my numbers from November 2018 to 2019.
    I refuse to take a statin, even though my CAC SCAN score is 135.
    54 year old male. Cardiologist thinks I may have Hypotrophic cardiomyopathy. Let me know if I can help with your project. I live in Whitby Ontario Canada.
    NOVEMBER 1 2018

    –===== CholesterolCode.com/Report v0.9.5.15 =====–
    • Male • 53 • Coffee: 2 cups/day •
    • 20 on years on Standard American •
    • 0h water fasted • Cholesterol Rx: false •

    Total Cholesterol: 186 mg/dL 4.80 mmol/L
    LDL Cholesterol: 126 mg/dL 3.27mmol/L
    HDL Cholesterol: 36 mg/dL .92mmol/L
    TG Cholesterol: 119 mg/dL 1.34mmol/L

    ———RISK REPORT———
    Atherogenic Index of Plasma: 0.163 mg/dL >>> Medium Risk Third
    —-> Go to https://tinyurl.com/ycccmmnx for more on AIP

    Framingham Offspring: 1.6 Odds Ratio >>> Very High Risk
    —-> Go to https://tinyurl.com/y5fc5adl for more on this Framingham study

    Jeppesen: >>> Medium Risk Third
    —-> Go to https://tinyurl.com/y63xp7lj for more on the Jeppesen study

    Cholesterol Remnants: 24 mg/dL >>> 0.27 mmol/L >>> Very High Risk
    —-> Go to https://tinyurl.com/y84u92wm for more on Cholesterol Remnants

    Friedewald LDL-C: 126 | Iranian LDL-C: 148
    TC/HDL Ratio in mg/dL: 5.17
    TG/HDL Ratio in mg/dL: 3.31 | TG/HDL Ratio in mmol/L: 1.46

    JUNE 21 2019

    –===== CholesterolCode.com/Report v0.9.5.15 =====–
    • Male • 54 • Coffee: 2 cups/day •
    • 3 on months on Keto (less than 20g carbs) •
    • 11h water fasted • Cholesterol Rx: false •

    Total Cholesterol: 227 mg/dL 5.87 mmol/L
    LDL Cholesterol: 169 mg/dL 4.36mmol/L
    HDL Cholesterol: 37 mg/dL .96mmol/L
    TG Cholesterol: 106 mg/dL 1.20mmol/L

    ———RISK REPORT———
    Atherogenic Index of Plasma: 0.097 mg/dL >>> Lowest Risk Third
    —-> Go to https://tinyurl.com/ycccmmnx for more on AIP

    Framingham Offspring: 1.6 Odds Ratio >>> Very High Risk
    —-> Go to https://tinyurl.com/y5fc5adl for more on this Framingham study

    Jeppesen: >>> Medium Risk Third
    —-> Go to https://tinyurl.com/y63xp7lj for more on the Jeppesen study

    Cholesterol Remnants: 21 mg/dL >>> 0.24 mmol/L >>> Very High Risk
    —-> Go to https://tinyurl.com/y84u92wm for more on Cholesterol Remnants

    Friedewald LDL-C: 169 | Iranian LDL-C: 175
    TC/HDL Ratio in mg/dL: 6.14
    TG/HDL Ratio in mg/dL: 2.86 | TG/HDL Ratio in mmol/L: 1.25

    SEPT 9 2019

    –===== CholesterolCode.com/Report v0.9.5.15 =====–
    • Male • 54 • Coffee: 2 cups/day •
    • 6 on months on Keto (less than 20g carbs) •
    • 6h water fasted • Cholesterol Rx: false •

    Total Cholesterol: 193 mg/dL 5 mmol/L
    LDL Cholesterol: 134 mg/dL 3.47mmol/L
    HDL Cholesterol: 34 mg/dL .89mmol/L
    TG Cholesterol: 125 mg/dL 1.41mmol/L

    ———RISK REPORT———
    Atherogenic Index of Plasma: 0.2 mg/dL >>> Medium Risk Third
    —-> Go to https://tinyurl.com/ycccmmnx for more on AIP

    Framingham Offspring: 1.6 Odds Ratio >>> Very High Risk
    —-> Go to https://tinyurl.com/y5fc5adl for more on this Framingham study

    Jeppesen: >>> Medium Risk Third
    —-> Go to https://tinyurl.com/y63xp7lj for more on the Jeppesen study

    Cholesterol Remnants: 25 mg/dL >>> 0.28 mmol/L >>> Very High Risk
    —-> Go to https://tinyurl.com/y84u92wm for more on Cholesterol Remnants

    Friedewald LDL-C: 134 | Iranian LDL-C: 159
    TC/HDL Ratio in mg/dL: 5.68
    TG/HDL Ratio in mg/dL: 3.68 | TG/HDL Ratio in mmol/L: 1.58

    NOVEMBER 21 2019

    ===== CholesterolCode.com/Report v0.9.5.15 =====–
    • Male • 54 • Coffee: 2 cups/day •
    • 8 on months on Keto (less than 20g carbs) •
    • .5h water fasted • Cholesterol Rx: false •

    Total Cholesterol: 221 mg/dL 5.72 mmol/L
    LDL Cholesterol: 160 mg/dL 4.14mmol/L
    HDL Cholesterol: 49 mg/dL 1.26mmol/L
    TG Cholesterol: 63 mg/dL .71mmol/L

    ———RISK REPORT———
    Atherogenic Index of Plasma: -0.249 mg/dL >>> Lowest Risk Third
    —-> Go to https://tinyurl.com/ycccmmnx for more on AIP

    Framingham Offspring: 0.7 Odds Ratio >>> Low Risk
    —-> Go to https://tinyurl.com/y5fc5adl for more on this Framingham study

    Jeppesen: >>> Medium Risk Third
    —-> Go to https://tinyurl.com/y63xp7lj for more on the Jeppesen study

    Cholesterol Remnants: 12 mg/dL >>> 0.14 mmol/L >>> Low Risk
    —-> Go to https://tinyurl.com/y84u92wm for more on Cholesterol Remnants

    Friedewald LDL-C: 159 | Iranian LDL-C: 136
    TC/HDL Ratio in mg/dL: 4.51
    TG/HDL Ratio in mg/dL: 1.29 | TG/HDL Ratio in mmol/L: 0.56

    1. Have you considered Pauling Therapy? Vitamin C and Lysine. I’d give that go if I were you.

      Also, could you tell me where you got your CAC scan done in Ontario? My brother is looking to get it done but he hasn’t been able to find a place to get it done.

  35. I live in Australia & would love to participate if possible.
    Total cholesterol is 11.5 mmol
    LDL 8.9 mmol
    HDL 2.3 mmol
    Trig .04

  36. Hi Dave

    How will you be selecting people for this experiment? Will you consider people with established disease, family history, MI survivors ?

  37. I would also be interested in participating. I am also a hyper responder. All my numbers are excellent except the high LDL cholesterol.

    My blood pressure is also excellent.

  38. Hi Dave,

    Love what you’re doing improving general Lipoprotein knowledge,
    It occured to me if you’re doing a study, The mobile app I’m already using for my records has a clinic backend.
    Might be worth exploring as it makes it easy to share the data

    The other thing, would be to ensure you get a good sampling across the world, Places like here in Australia for instance, we can get the blood testing and most of the other tests for free under medicare, So might make financial sense to maximize the reach of the study.

  39. Sorry, Appended to my last one,

    Forgot to mention, the MyTherapy Pro is Free and In Beta currently, So costs, nothing, Would potentially be even useful to do no directed studies of LDL and Low Carb Diets, I’d be happy to send my data

  40. *The next time I read a blog, I hope that it doesnt disappoint me as much as this one. I mean, I know it was my choice to read, but I actually thought youd have something interesting to say. All I hear is a bunch of whining about something that you could fix if you werent too busy looking for attention.

  41. Hi Dave,

    3 years on HFLC diet. I would love to help. 38 year old female.
    Total cholesterol 270
    HDL 77
    Triglycerides 44
    LDL 184
    VLDL 9

  42. Hello Dave,
    What a great project!
    I’d love to participate
    32, Male, Lean and active, Keto for 8 months, Carnivore for 6.
    My recent blood work is as follows:
    Total Cholesterol : 386
    LDL : 301
    HDL : 75
    Triglycerides : 48
    Apo b-100 : A2.03
    I live in Vancouver, BC.

  43. *When I originally commented I clicked the -Notify me when new comments are added- checkbox and now each time a comment is added I get four emails with the same comment. Is there any way you can remove me from that service? Thanks!

    1. Hi – I don’t believe this is anything within our control, as it’s an automated feature. However, within the emails you’ve received there should be an unsubscribe/opt out option so you no longer receive them. I hope that helps – if not, please let me know.

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  45. Can I just say what a relief to find somebody who really is aware of what theyre speaking about on the internet. You positively know how you can bring a difficulty to gentle and make it important. Extra folks need to learn this and understand this aspect of the story. I cant imagine youre no more popular because you undoubtedly have the gift.

  46. Thank you for your work, so important. If looking for additional Hyper-responder:

    My labs, NMR LipoProf (LabCorp) 6/8/2019:

    LDL-P 1636
    LDL-C 150

    HDL-C 105
    Triglycerides 60
    Cholesterol, Total 267
    HDL-P (Total) 34.1
    Small LDL-P <90
    LDL, Size 21.7

    LP-IR Score <25

  47. Thank you for the good writeup. It in fact was a amusement account
    it. Look advanced to far added agreeable from you!

    By the way, how could we communicate?

  48. Just donated – wish it could be more as what you do FANTASTIC – will donate further when possible. Happy to be lab rat. Your calculator says I’m borderline LMHR. 65 y/old female in Australia, fit, low body fat. Everything in good ranges except my LDL. CAC scan 1.5 (yes 1.5). Am long term HFLC/sometimes keto, Use IF/fasting. Not on any medications. My functional medicine doc onside.

  49. Excellent blog you have here but I was wanting to know if you knew of any discussion boards that cover the same topics discussed here? I’d really love to be a part of online community where I can get advice from other knowledgeable individuals that share the same interest. If you have any suggestions, please let me know. Appreciate it!

  50. Fifty seven year old male…I’ve been on a LCHF/ carnivore diet for about 1 year. On blood pressure meds only. Recent lipid panel:
    Total: 529 mg/dL
    LDL: 433
    HDL: 80
    Trigl: 77
    Baseline CAC score: 17
    GP freaked, said he never saw numbers that high before. He’s now trying to prescribe a statin and refer me to a cardiologist. Repeated lipid panel per his request. 1 week later after altering my diet to higher carb low fat. Repeat lipid panel results:
    Total: 398
    LDL: 310
    HDL: 72
    Trigl: 77
    My numbers 4 years ago when on Pravachol and standard American diet.
    Total: 157
    LDL: 89
    HDL: 48
    Trigl: 102

  51. I absolutely love your site.. Great colors & theme. Did you build this web site yourself? Please reply back as I’m trying to create my own site and would like to learn where you got this from or just what the theme is called. Thanks!

  52. Been listening to Ivor and Dave podcasts…especially discussion of Attia point of view. Great Stuff

    Have been a LCHF loose for a few years which is heartily encouraged by my PCP. Bacon grease is his oil of choice with no reservations.
    Total C 271mg/dL
    Tri 58
    HDL 65
    LDL-C 194
    VLDL 12
    LDL-P 2057
    Small LDL 223 Pattern A

    I am doing fabulously at 76 yrs. 6’2″ 160lbs with a belly left over from years and years of SAD. My Omron scale says I have about 17% body fat and 35% muscle. Am moderately athletic with my game of softball in my community…three times a week..before CV-19.
    I use a Freestyle CBG monitor as my blood glucose tends to ave around 115 to 125 during the day and around 100 while sleeping.
    My CAC score in early Jan 2020 was 444. The CGM has shown me I have been a walking diabetic during the days but at blood draws 12 hour fasting, always would see glucose around 95 to 105. So now working on reducing the CAC.
    Thanks for all you are doing.

    A1C 5.4

  53. Started Keto 3 mo ago and had labs drawn today. 39 yo Female
    LDL Calculated-252

    Interested in your study. MD immediately suggested STATINS. I said hell no!!!

  54. Hmm it seems like your website ate my first comment (it was extremely long) so I guess I’ll just sum it up what I had written and say, I’m thoroughly enjoying your blog. I too am an aspiring blog writer but I’m still new to everything. Do you have any tips for inexperienced blog writers? I’d really appreciate it.

  55. Hi there. Im a 48year old male living in Denmark. Im 190cm and 84 kgs. Relatively active. If I can be of help I would like to participate in this project. The science of LCHF is the future for health.
    Im 3 months into keto and my lipid values are:
    Total (P): 8,4 mmol/l
    HDL(P): 1,5 mmol/l
    LDL(P): 6,4 mmol/l
    TRI(P): 1,0 mmol/l

    Im new to the low carb lifestyle and Im surprised at the effect it has had on my body and energy. Im so happy that I was able to find a website with the information you provide. I really hope this project goes ahead. Thank you

  56. 57 year old male. LCHF for about 2-years now.
    Restricting carbs greatly reduced my cholesterol – got me off a statin. Numbers have been going up rather consistently though w/ no real change in diet. I work out a few times a week (resistance training) but not much cardio of late. Just got new labs today…

    Total: 336
    Tri: 61
    HDL: 120
    LDL: 204

    …doc concerned. I feel like w/ the low triglycerides and high HDL it shouldn’t be concerning, but he’s just not happy w/ that LDL (and the total of course).

  57. Great cause, I will help with donation, and participate too if possible.
    • Female • 59 • Coffee: 0 cups/day •
    • 30 on months on LCHF (20g to 120g carbs) •
    • 14h water fasted • Cholesterol Rx: false •

    mg/dL => Total: 371 | LDL: 270 | HDL: 90 | TG: 56

  58. Pretty sure I am one of those borderline cases? I would like to know, but regardless, I have donated to the cause.

    Triglycerides 101
    Cholesterol 410
    HDL 67
    LDL 323

    LDL-P >3500
    HDL-P (Total) 27.5
    Small LDL-P 435
    LDL size 22.0
    LP-IR score <25
    Large VLDL-P <0.8
    Small LDL-P 435
    Large HDL-P 9.8
    VLDL size (not sufficient…)
    LDL Size 22.0
    HDL size 9.8

  59. Hi Dave,
    I’d love to participate as a borderline LMHR. I’m 58 years old, and have experimented with diet since the 1980’s. Back then it was extremely low fat, high carb for me and my total cholesterol was 119 (can’t recall the specifics). Around 1999 I went to low carb, higher fat and saw the total reading increase to about 155. I’m 5’10” and 165 lbs historically regardless of dietary approach.
    For the last 4.5 years:
    – full keto with less than 20 grams carbs per day
    – current readings are: 245 total, HDL 82, LDL 157, TG 31
    Let me know if I can help,

  60. Hi Dave, I’m one of the many people you met at the 2019 Low Carb Denver. I’m happy to be a member of the LMHR study.

    I’ve been on Keto since February 2017 but only saw the high HDL after donating blood this month after receiving a letter saying my Cholesteral was 343 and I should see a doctor about it.

    I’m 66 and a road bike racer. I’, 5’10” and weigh 159 pounds. I ride my bike 20 to 50 miles daily.

    Here are the stats from tests last week:
    Cholesterol 327
    Trigylceride 44
    Cholesterol/HDL Ratio 3.5
    HDL Cholesterol 94
    Non­HDL Cholesterol 233
    LDL Cholesterol, Calculated 224
    VLDL Cholesterol 9

    Please let me know if you need any other info.
    I have my annual physical with my PCP on September 15 and although he know I do keto and understand the basics, he has not seen these cholesterol numbers before, so I plan on doing the Feldman Protocol prior to the blood tests.


  61. Hi Dave

    64 years old Australian. . Likely candidate based on Lipid stats. VO2 Max 48; Alpinist. Cyclist. Never felt healthier. Keto/borderline Carnivore since 2016.

    Cholesterol total. 7.41 mmol/L
    Cholesterol LDL (measured) 5.30
    Cholesterol LDL (non HDL) 5.43
    Triglycerides 0.41
    Cholesterol HDL. 1.98

  62. Are you still seeking LMHR people for the study? If so I am interested to participate. Age 63, LCHF diet for 1.7 yrs with detailed tracking for most of 1.5 years (food, macros, weight, IF timeframes, Blood glucose and ketone levels at times). Height is 5’7″, weight 138. Active, athletic male.

    10.24.19 – lipid panel testing (with similar results 6.26.19) and very different results before LCHF changeover in 2017.
    total = 307
    HDL= 88
    LDL- 202

    I can provide more info of course. Look forward to hear from you.

    1. Hi Robert, as soon as we have any updates on the timeline, participation, etc we’ll be sure to have a post to let people know. Currently there’s still some legwork being done in the background before that. 🙂

  63. Not sure if you still need any data/ volunteers. 36 yo, I used to be keto, now I’m just lowish carb. Zero sugar, or close to it. I fast a good bit and am very active. I’d really like to get CGM and see what sort of excursions I get when I do eat carbs, but I find I can achieve equally great results with low, smart carb eating, paired with fasting and exercise. As opposed to strict keto say.

    TC: 268
    HDL: 63
    LDL: 197
    Trigs: 57
    Fasting glucose: 73

    1. Hi – we’ll be sure to post any updates on the study timeline, and other relevant info as soon as we’re ready to move on to next steps – currently there’s still legwork to be done. 🙂

  64. I was curious if you ever thought of changing the structure of your site?
    Its very well written; I love what youve got to say.

    But maybe you could a little more in the way of content so people could connect with it better.
    Youve got an awful lot of text for only having one
    or two images. Maybe you could space it out better?

    1. Hi, thanks for the feedback. It’s appreciated. Depending on what the post is about images may be used more often or less often, it just depends. Since is the main landing page of the LMHR study we wanted to keep it pretty straightforward. 🙂

  65. Would like to be part of this study. My Dr wants to put me on Lipitor . Keto diet 4 mos. Ratio 2.96:1, TG ratio .6315:1 Large HDL-p 16.2 LDL size 22.3. Small LDL -p 165 Total LDL-p 1615

    Very athletic female
    Age 56

    Total 282
    LDL 175
    HDL 95
    TG 60

    Thank you . I am trying to reduce sat. Fats to 22g /day. To lower LDL . Recheck 3 mos.

    1. Hi Susan – we’ll be sure to post any updates we have when we’re ready to move to the next steps, currently there’s some legwork being done before that. 🙂

  66. I’m Interested in participating in this study. 56yr/ Female. I’ve been low carb carnivore for two years. In the past my lipids were normal except for high Trigs. Now it is the following:

    Total 346 *(349)
    HDL 94 (105)
    LDL 226 (230)
    Trigs 115 (44)
    *last years labs (2019)
    I also requested Fraction lipid panel which were all within a normal range except the following:
    LDL P 2308
    VDL SIZE 48.2
    note: I am retesting as my current labs were not fasted. I believe it is the reason for having higher trigs this year.

  67. I will right away grab your rss feed as I can’t find your email subscription link or e-newsletter service. Do you have any? Kindly let me know so that I could subscribe. Thanks.

  68. I’ve been eating an animal based diet for last 2 years. Keto for the 3 years prior. Similar lipid panels as reported above. I would love to be part of this study. I live in North West US.

  69. Hello just wanted to give you a quick heads up and let you know
    a few of the images aren’t loading correctly. I’m not sure why but I think its a linking issue.
    I’ve tried it in two different browsers and both show the
    same results.

  70. excellent publish, very informative. I wonder why the opposite specialists of this sector don’t understand this. You should continue your writing. I am sure, you have a great readers’ base already!

  71. When I originally commented I clicked the “Notify me when new comments are added”
    checkbox and now each time a comment is added I get several
    e-mails with the same comment. Is there any way you can remove me from that service?
    Thanks a lot!

  72. I am 52 with a normal BMI and I exercise pretty much daily. I am definitely a LMHR. I have a record of all 14 lipid tests dating back to 2008. Up until I switched to LCHF, my cholesterol numbers were pretty normal. I’ve been on IF & LCHF for 2.5 years and feel great. My latest scores (26 Nov 2020) are as follows:
    Total Chol: 334
    Trig: 68
    HDL-C: 61
    LDL-C: 277

    (Previous: 6 Oct 2020)
    Total Chol: 367
    Trig: 88
    HDL-C: 66
    LDL-C: 295 (highest score ever recorded)

    Before switching to LCHF, my LDL-C was never over 140.

    Last week, I had a CAC score done and scored 43. It’s the first test I’ve had, so nothing to compare it to. When I showed the doctor my blood work, he was horrified that I wasn’t on statins and even more so when I said I wasn’t planning on taking any.

    I know my HDL numbers may not be high enough to participate in your research, but if I can, that would be great. I should also mention that I live in Thailand.

    Thank you for all the work you do.

  73. Hmm is anyone else encountering problems with the images on this blog
    loading? I’m trying to figure out if its a problem on my end or if it’s the blog.
    Any feedback would be greatly appreciated.

  74. Hi Dave / Siobhan. Very interested in the study and would love to be a subject. I have my Standard Lipid Panels (LDL-C, HDL-C, VLDL, Trigs) history for the last 6-7 years. 41 y/o male ultrarunner who went Low Carb / Keto in mid-2016 which is when I noticed the jump in LDL/HDL and drop in Trigs. This year, after getting Omega 3 Index test in January (6.36 Index), started taking 2-3 grams EPA/DHA and tablespoon MCT oil daily, but also started eating more carbs in the form of homemade sourdough and my Total Cholesterol jumped ~65 points with 70% of the increase in LDL (Omega Index also jumped to 13.7) As a runner, I’m lean at around 140 pounds and 5’7″. Latest Lipid Panel is:
    Total: 322
    LDL-C: 199
    HDL-C: 119
    Trig: 49
    VLDL: 9
    Apo-B = 147
    Anything I can do aside from my donation to help the study?! Highly interested.

    1. Also, amazing I forgot, but in late July was infected with Salmonella. Maybe that is the culprit responsible for the latest increase in LDL on my September and December Lipid panels..

  75. Lipid Profile (=Panel) report of December 19,2020(mg/dL):
    Total C 252
    LDL C 187
    HDL C 49
    TG 80
    Following aspects may please be noted:
    Age 83. LCHF since 5 years.19 lipid profile reports available. From INDIA. Vegetarian but do eat milk and milk products, eggs, gelatin. Flex seed but no fish or fish oil.
    Willing to be a volunteer.

  76. An impressive share! I have just forwarded this onto a colleague who has
    been conducting a little research on this. And he in fact ordered me lunch
    because I discovered it for him… lol. So let me reword this….

    Thanks for the meal!! But yeah, thanx for spending time to talk about this subject
    here on your blog.

  77. Everyone loves what you guys are up too. This kind of clever work and reporting!
    Keep up the superb works guys I’ve incorporated you guys to our blogroll.

  78. Oh my goodness! Impressive article dude! Many thanks, However I am experiencing problems with
    your RSS. I don’t understand why I can’t subscribe to it.
    Is there anyone else having the same RSS problems?

    Anyone who knows the solution will you kindly respond? Thanx!!

  79. I would love to be involved in the study!

    5 days post heart attack on a low fat diet with very low cholesterol numbers TG:HDL 3.1 30%bf

    currently 3 years eating low carb, time restricted cholesterol in the “high” range TG:HDL .89 17%bf

    I eat 5-10X the RDA for cholesterol now.

    Currently on no prescription meds.
    Thanks for all the work you have all done!

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